E. Klein

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.

T-Cell-Mediated Killing in Glioblastoma Organoids induced by Adenoviral Delivery of the CIITA Transgene

This study shows that adenoviral delivery of CIITA enhances T-cell mediated killing of glioblastoma organoids, with some MHC-II-independent immune responses observed.

Systemic Sclerosis dermal fibroblast exosomes trigger a Type 1 interferon response in keratinocytes through the TBK/JAK/STAT signalling axis

Efficient and sustained optogenetic control of sensory and cardiac systems

This paper introduces ChReef, an improved optogenetic tool with enhanced performance in sensory and cardiac systems, demonstrating its effectiveness in restoring visual and auditory function.

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

Cultivation of Exoelectrogenic Bacteria in Conductive DNA Nanocomposite Hydrogels Yields a Programmable Biohybrid Materials System

This study cultivates exoelectrogenic bacteria in conductive DNA nanocomposite hydrogels to create a programmable biohybrid system that can release and degrade on demand.

Pre-existing SIV Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques

This study shows that pre-existing SIV infection in macaques increases susceptibility to tuberculosis by impairing immune control of M.tb.