Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging
S. B. Poudel, D. F. Benayed, R. R. Ruff, G. Yildirim, M. Dixit, M. B. Schaffler, R. Korstanje, L. Robinson, R. A. Miller, D. Harrison, R. Strong, S. Yakar
This study evaluates the effects of methylene blue and mitoquinone on skeletal aging in mice, finding no significant reduction in age-related bone loss despite some in vitro benefits.
bioRxiv · Jun 16, 2023Pharmacology & Toxicology