R. A. Miller

This study shows that soquelitinib inhibits ITK and reduces T cell-mediated inflammation in multiple murine models.

This study evaluates the effects of methylene blue and mitoquinone on skeletal aging in mice, finding no significant reduction in age-related bone loss despite some in vitro benefits.

The paper identifies that subterranean mammals have abundant high-molecular-mass HA due to genetic changes, which may aid in cancer resistance and adaptation to hypoxic environments.

This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.

This study shows that exposing female mice to adult female odors during early life extends their lifespan, while male lifespan is unaffected by such odors.

This study shows that aging increases brain iron levels through elevated local hepcidin expression, leading to reduced iron export and accumulation in both cytosolic and mitochondrial compartments.

This study shows CLIP-170 directly binds F-actin, independent of formin interaction, and suggests this binding may reduce MT stability in actin-rich regions.

This study shows that canagliflozin increases adenoma burden in female APCMin/+ mice, suggesting complex, cell-non-autonomous mechanisms and sex differences in drug effects.

The paper identifies genetic factors in Muribaculaceae bacteria that correlate with differential response to acarbose treatment in mice using metagenome-assembled genomes.

This study shows canagliflozin extends lifespan in male but not female mice, likely by reducing peak glucose levels, similar to acarbose.

This study shows that acarbose treatment in mice increases gut microbiota-derived short-chain fatty acids, which correlate with longer lifespan, suggesting a role for microbiota in acarbose's longevity effects.