M. Dixit

Deletion of absent in melanoma (AIM) 2 gene alters bone morphology

This study investigates the impact of AIM2 gene deletion on bone morphology in mice, finding increased cortical thickness and decreased trabecular bone volume and BMD in aged AIM2 null females.

Role of Tyrosine Phosphorylation in PTP-PEST

The paper investigates how tyrosine phosphorylation affects PTP-PEST's structure and function by identifying specific phosphorylation sites and their impact on substrate binding and catalytic conformation.

An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal stem cells

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging

This study evaluates the effects of methylene blue and mitoquinone on skeletal aging in mice, finding no significant reduction in age-related bone loss despite some in vitro benefits.

In-silico identification of Tyr232 in AMPKα2 as a dephosphorylation site for the protein tyrosine phosphatase PTP-PEST

The paper identifies Tyr232 in AMPKα2 as a dephosphorylation site for PTP-PEST using bioinformatics and molecular dynamics simulations.

The SPICA Coarse-Grained Force Field for Proteins and Peptides

The paper develops and improves a coarse-grained force field for proteins and peptides, showing good performance in simulating membrane protein behavior and interactions.

Oral glucose feeding enhances adherence of quiescent lymphocytes to fibronectin via non-canonical insulin signalling.

The paper shows oral glucose increases lymphocyte adhesion to fibronectin via non-canonical insulin signaling involving IGF-1R and PLCγ1.

Protein tyrosine phosphatase-PEST (PTP-PEST) mediates hypoxia-induced endothelial autophagy and angiogenesis through AMPK activation

This study shows that PTP-PEST promotes hypoxia-induced endothelial autophagy and angiogenesis by activating AMPK.

Altered kinetics of circulating progenitor cells in cardiopulmonary bypass (CPB) associated vasoplegic patients: A pilot study

This study examines changes in circulating progenitor cells during CPB and finds that reduced early CD34+ and CD34+CD133+ HSC counts predict clinically significant vasoplegia.

IQGAP2 acts as a tumor suppressor in breast cancer and its reduced expression promotes cancer growth and metastasis by MEK/ERK signalling pathways