Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42
D. L. Kober, M. D. Stuchell-Brereton, C. E. Kluender, H. B. Dean, M. R. Strickland, D. F. Steinberg, S. S. Nelson, B. Baban, D. M. Holtzman, C. Frieden, J. M. Alexander-Brett, E. D. Roberson, Y. Song, T. J. Brett
This study investigates TREM2 interactions with ApoE and Aβ1-42 using biophysical methods, revealing distinct binding surfaces and a potential role for sTREM2 in inhibiting Aβ polymerization.
Alzheimer's & Dementia · Oct 8, 2020Peer-reviewedBiophysics