M. D. Stuchell-Brereton

This study investigates the biophysical mechanism of allosteric regulation of actin capping protein using single-molecule FRET and MD simulations, revealing conformational changes linked to ligand binding.

This study investigates how the disordered N-terminal tail of the SARS-CoV-2 Nucleocapsid protein enhances RNA binding affinity and modulates interactions with RNA.

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

This study investigates TREM2 interactions with ApoE and Aβ1-42 using biophysical methods, revealing distinct binding surfaces and a potential role for sTREM2 in inhibiting Aβ polymerization.

This study investigates the SARS-CoV-2 nucleocapsid protein's dynamics, disorder, and RNA phase separation using single-molecule spectroscopy and simulations, revealing its multivalent RNA binding properties and phase separation behavior.