Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling
O. Ogunlusi, M. Sarkar, A. Chakrabarti, D. Boland, T. Nguyen, J. Sampson, C. Nguyen, D. Falis, Y. Jones-Hall, L. Fu, B. Mallick, A. Keene, J. Jones, T. R. Sarkar
This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.
bioRxiv · Mar 19, 2024 · PreprintCancer Biology