L. Fu

Prdm16-dependent antigen-presenting cells induce tolerance to intestinal antigens

This study identifies Prdm16-dependent tolerogenic dendritic cells (tDC) that induce regulatory T cells to promote oral tolerance to food and microbiota antigens in mice and humans.

Two mechanisms of photoenergy regulation revealed by kinetic behaviors of chlorophyll fluorescence during light adaptation

The paper identifies two mechanisms of photoenergy regulation in PSII using chlorophyll fluorescence kinetics: one involving PsbS-mediated NPQ and another involving zeaxanthin and lutein disrupting energy transfer to P680.

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.

Ultraviolet B acts as a dietary restriction mimetic by targeting mitochondrial bioenergetics.

This study shows UVB exposure mimics dietary restriction by altering mitochondrial bioenergetics in C. elegans and human cells, triggering metabolic re-wiring and requiring mitochondrial fusion for recovery.

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

DeltaAI: Semi-Autonomous Tissue Grossing Measurements and Recommendations using Neural Radiance Fields for Rapid, Complete Intraoperative Histological Assessment of Tumor Margins

DeltaAI uses Neural Radiance Fields to create 3D tissue models for faster and more accurate intraoperative tumor margin assessment in Mohs Micrographic Surgery.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

Highly specialized carbohydrate metabolism capability in Bifidobacterium strain associated with intestinal barrier maturation in early preterm infants

Full-mouth photoacoustic/ultrasound imaging of the periodontal pocket with a compact intraoral transducer

This paper introduces a compact intraoral transducer for full-mouth photoacoustic/ultrasound imaging of periodontal pockets, demonstrating its clinical relevance with in vivo imaging accuracy within 7% of clinical measurements.

A miniaturized ultrasound transducer for monitoring full-mouth oral health: a preliminary study

This study develops a miniaturized ultrasound transducer for full-mouth oral health monitoring, demonstrating high-resolution imaging and accurate gingival thickness measurement.

Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.

Structure of Infective Getah Virus at 2.8 A-resolution Determined by Cryo-EM

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data

The paper analyzes metagenomic and metatranscriptomic data to understand factors driving vaginal microbiota composition and function, finding that transcriptional activity varies with community context.

Converting Muscle-mimetic Biomaterials to Cartilage-like Materials

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-CoV-2 Infection in vitro

This study shows apabetalone reduces ACE2 and DPP4 expression and inhibits SARS-CoV-2 infection in vitro, suggesting it could be a potential therapeutic for COVID-19.

Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

Structural basis of SARS-CoV-2 polymerase inhibition by Favipiravir

This paper determines the cryo-EM structure of Favipiravir bound to SARS-CoV-2 polymerase, revealing its base-pairing mechanism and implications for antiviral drug development.

The role of cation diffusion facilitator CDF-1 in lipid metabolism in Caenorhabditis elegans

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

The paper identifies BET inhibitors as potential cardio-protective drugs that block inflammation-induced cardiac dysfunction and SARS-CoV-2 infection in pre-clinical models.

Indole acetic acid and lipopeptide-producing endophytic bacteria from Taxus chinesis: toxicity evaluation of metabolic products

The paper screens endophytic bacteria from Taxus chinensis for IAA and lipopeptide production, identifies non-toxic strains, and suggests their potential for biofertilizer use.

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

PRR14 Overexpression Promotes Cell Growth, Epithelial to Mesenchymal Transition and Metastasis of Colon Cancer via the AKT Pathway

Ultra-high throughput multiplexing and sequencing of >500 bp amplicon regions on the Illumina HiSeq 2500 platform

The paper describes modifications to the Illumina HiSeq 2500 platform for higher throughput amplicon sequencing with improved quality and multiplexing capabilities.