A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression
S. Ghannoum, D. Fantini, M. Zahoor, V. R. Farhan, S. Phuyal, W. L. Netto, O. Sorensen, A. Iyer, D. Sengupta, L. Prasmickaite, G. M. Malandsmo, A. Kohn-Luque, H. Farhan
The paper develops a computational model to study cell migration traits in tumor progression and finds that Giantin depletion increases intravasation, validated by lower Giantin levels in circulating tumor cells.
bioRxiv · Apr 25, 2022Cancer Biology