D. Sengupta

Intra-DNA k-mer Conservation Patterns Encode Evolutionary Selection of Variants

The paper introduces kGain, a metric quantifying k-mer frequency shifts due to mutations, and shows it predicts adaptive potential across species and experimental systems.

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

Elevated levels of lamin A promote HR and NHEJ-mediated repair mechanisms in etoposide-treated ovarian cancer cells

The paper shows that elevated lamin A in ovarian cancer cells enhances DNA repair via HR and NHEJ mechanisms in response to etoposide treatment.

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression

This paper identifies two distinct mechanisms by which SARS-CoV-2 accessory proteins ORF7a and ORF3a downregulate MHC-I surface expression to evade immune detection.

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

The paper develops a computational model to study cell migration traits in tumor progression and finds that Giantin depletion increases intravasation, validated by lower Giantin levels in circulating tumor cells.

Microdynamics of lamin A Ig-fold domain regulates higher order assembly of the protein

This study investigates how mutations in the lamin A Ig-fold domain affect its dynamics and assembly into the nuclear lamina using live cell imaging, FCS, and MD simulations.

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

Microfluidic system-based time-course tracking of physical proximity between cells and its effect on gene expression for elucidating live single cancer-immune cell interactions

This study tracks physical proximity between NK and TNBC cells over time using a microfluidic system and links it to gene expression changes, revealing transcriptional memory in immune-cancer interactions.

Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1

The paper shows that the N-terminus of hCTR1 regulates copper uptake by coordinating Cu(I) and facilitating its reduction from Cu(II).

Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1

This paper investigates the conformational dynamics of the N-terminal domain of CXCR1 during ligand binding using simulations and NMR validation, showing ligand-induced conformational changes.

Nuclear Morphology Optimized Deep Hybrid Learning (NUMODRIL): A novel architecture for accurate diagnosis/prognosis of Ovarian Cancer

This paper introduces a novel deep hybrid learning architecture, NUMODRIL, for classifying ovarian cancer tissues based on nuclear morphology and lamin protein distribution, achieving high accuracy and efficiency.

Wavelet coherence phases decode the universal switching mechanism of Ras GTPase superfamily

The paper uses wavelet coherence analysis to show conserved phase coupling between Switch I and II regions in Ras GTPases, which is disrupted in oncogenic mutants.

Systematic hormone-metabolite network provides insights of high salinity tolerance in Pongamia pinnata (L.) pierre

This study investigates hormonal and metabolic responses in Pongamia pinnata under salinity stress, revealing key adaptations that confer salt tolerance.

Deep Active Lesion Segmentation

This paper introduces DALS, a lesion segmentation framework combining CNNs and ACMs, showing better performance on small datasets across brain, liver, and lung images.

Age but not disease progression defines CD4+ and CD8+ T stem cell memory levels in human retroviral infections: contrasting effects of HTLV-1 and HIV-1

This study compares CD4+ and CD8+ TSCM levels in HTLV-1 and HIV-1 infections, finding age-driven accumulation in HTLV-1 and age-related loss in HIV-1 after treatment.