Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays
D. Monteferrario, M. David, S. K. Tadi, Y. Zhou, I. Marchetti, C. Jeanneau, G. Saviane, C. F. Dupont, A. E. Martelli, L. Truong, J. Eshleman, C. Ng, M. Huston, G. D. Davis, J. D. Fontenot, , D. Fenard
This paper develops a lentiviral system to simultaneously repress multiple genes using zinc finger repressors, showing efficient and long-term gene silencing without DNA editing.
bioRxiv · Jan 17, 2024Bioengineering