M. David

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

This paper develops a lentiviral system to simultaneously repress multiple genes using zinc finger repressors, showing efficient and long-term gene silencing without DNA editing.

Learning a deep language model for microbiomes: the power of large scale unlabeled microbiome data

This paper trains a self-supervised microbial language model on human gut microbiome data to improve prediction of IBD and diet patterns, showing better performance than baseline methods.

LDLR-mediated targeting and productive uptake of siRNA-peptide ligand conjugates in vitro and in vivo

The paper develops and evaluates siRNA-peptide conjugates targeting LDLR for siRNA delivery in vitro and in vivo.

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

This study identifies SLFN12 as an HIV-1 restriction factor that inhibits viral replication and reactivation through codon-usage dependent post-transcriptional block in CD4+ T cells.

High fat diet changes bacterial signatures in the murine pancreas

This study shows that a high-fat diet alters bacterial DNA signatures in the pancreas of mice, suggesting potential bacterial translocation from the gut.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

Interaction of levothyroxine with bovine serum albumin: a spectroscopic assay

This study investigates the interaction between levothyroxine and bovine serum albumin using spectroscopic methods, finding ground-state complex formation and binding affinity characterized by hydrogen bonds and van der Waals forces.

On the origin of photoperiod non-responsiveness in barley

This study identifies the origin of photoperiod non-responsiveness in barley by analyzing genetic variation and haplotype relationships in wild and domesticated barleys.

Long-term intrahost evolution of methicillin-resistant Staphylococcus aureus among cystic fibrosis patients with respiratory carriage

This study examines the long-term intrahost evolution of MRSA in CF patients, identifying genomic diversity, adaptation, and selection pressures.