Author

D. Fignani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1

Frequent Co-Authors

F. Dotta· 3 shared G. E. Grieco· 3 shared G. Licata· 3 shared G. Sebastiani· 3 shared L. Marselli· 3 shared L. Nigi· 3 shared N. Brusco· 3 shared P. Marchetti· 3 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

F. Dotta

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Increased expression of viral sensor MDA5 in pancreatic islets and in hormone-negative endocrine cells in recent onset type 1 diabetic donors

L. Nigi, N. Brusco, G. E. Grieco, D. Fignani, G. Licata, C. Formichi, E. Aiello, L. Marselli, P. Marchetti, L. Krogvold, K. D. Jorgensen, G. Sebastiani, F. Dotta

This study shows increased MDA5 expression in pancreatic islets and hormone-negative endocrine cells in recent-onset T1D donors compared to non-diabetic controls.

bioRxiv · Nov 29, 2021Immunology

Reduced miR-184-3p expression occurring in Type 2 diabetic pancreatic islets protects β-cells from lipotoxic and proinflammatory apoptosis via a CRTC1-dependent mechanism

G. E. Grieco, N. Brusco, L. Nigi, C. Formichi, D. Fignani, G. Licata, L. Marselli, P. Marchetti, L. Salvini, L. Tinti, A. Po, E. Ferretti, G. Sebastiani, F. Dotta

The paper shows reduced miR-184-3p in T2D pancreatic islets protects β-cells from apoptosis by upregulating CRTC1, with NKX6.1 controlling miR-184-3p expression.

bioRxiv · Jan 4, 2021 · PreprintCell Biology

SARS-CoV-2 receptor Angiotensin I-Converting Enzyme type 2 (ACE2) is expressed in human pancreatic β-cells and in the human pancreas microvasculature

D. Fignani, G. Licata, N. Brusco, L. Nigi, G. E. Grieco, L. Marselli, L. Overbergh, C. Gysemans, M. L. Colli, P. Marchetti, C. Mathieu, D. L. Eizirik, G. Sebastiani, F. Dotta

This study shows ACE2 is expressed in human pancreatic β-cells and microvasculature, suggesting a potential link between SARS-CoV-2 and diabetes through β-cell infection or microvasculature involvement.

bioRxiv · Jul 23, 2020Cell Biology