A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation
V. C. B. Nguyen, C. Özden, K. Dong, O. Koc, A. P. Torres-Ocampo, N. Dziedzic, D. Flaherty, J. Huang, S. Sankura, N. L. Abromson, D. R. Tomchick, R. A. Fissore, J. Chen, S. C. Garman, M. Stratton
This study identifies a domain-swapped conformation in CaMKII that enables linker-mediated allosteric regulation, demonstrated through structural, computational, and live-cell analyses.
bioRxiv · Mar 24, 2024Biochemistry