J. Chen

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

This study identifies genomic heterogeneity and ploidy as markers of intrinsic resistance to PD-1 blockade in metastatic melanoma, with a decision tree model predicting resistance with high confidence.

Arterial arcades and collaterals regress under hemodynamics-based diameteradaptation: a computational and mathematical analysis

The paper shows that arterial loops regress under hemodynamics-based diameter adaptation in computational and mathematical models.

Two mechanisms of photoenergy regulation revealed by kinetic behaviors of chlorophyll fluorescence during light adaptation

The paper identifies two mechanisms of photoenergy regulation in PSII using chlorophyll fluorescence kinetics: one involving PsbS-mediated NPQ and another involving zeaxanthin and lutein disrupting energy transfer to P680.

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

This paper identifies a novel penetration ring formed by secreted proteins in the rice blast fungus after cell wall penetration, which persists at the plasma membrane interface during invasion.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

This study uses cryoET and deep learning to reveal structural differences in the tegument and envelope of EBV and KSHV virions compared to other herpesviruses.

Colony context and size-dependent compensation mechanisms give rise to variations in nuclear growth trajectories

The paper analyzes nuclear growth variations in hiPS cell colonies, finding context-dependent and inherited mechanisms shaping growth trajectories.

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via caspase BmICE

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection

This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.

Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone

This study shows that gut neuropeptide F (NPF) and its interaction with brain insulin and juvenile hormone regulate Drosophila aging through interorgan communication.

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

Structural basis for the transport and regulation mechanism of the Multidrug resistance-associated protein 2

This study determines the cryo-EM structures of MRP2 in three conformational states, revealing its transport mechanism and substrate recognition.

Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation

This study uses mechanical oscillation to enhance endosomal escape of mRNA delivered by lipid nanoparticles, improving transfection efficiency without harming cell viability or organelle integrity.

Aerial litter mimicry: a novel form of floral deception mediated by a monoterpene synthase

This study identifies a novel floral mimicry system where flowers resemble aerial litter, using a monoterpene synthase to attract pollinators.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics

The paper constructs a fine-scale recombination map in domestic chickens to study rapid evolutionary changes in recombination rates during domestication.

Small molecule NS11021 promotes BK channel activation by increasing inner pore hydration

This paper investigates how the small molecule NS11021 activates BK channels by increasing inner pore hydration through atomistic simulations.

Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles

This paper enhances laser lithotripsy efficiency using a PEDOT:PSS nanofluid, achieving significant improvements in stone ablation without increased thermal injury.

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation

This study presents cryo-EM structures of PKA-C bound to CFTR, revealing mechanisms of phosphorylation and reversible activation through catalytic interactions and conformational flexibility.

An orphan viral genome with controversial evolutionary status sheds light on a distinct lineage of flavi-like virus infecting plants

This study resolves the taxonomic controversy of SRAV, a plant-infecting flavi-like virus, by showing it belongs to the Flaviviridae family and triggers host RNAi responses.

Skeleton-forming responses of reef-building corals under ocean acidification

This study examines how four coral species form skeletons under acidified conditions, revealing diverse strategies and damage patterns.

2D Label-free Prediction of Multiple Organelles Across Different Transmitted-light Microscopy Images with Bag-of-Experts

This paper introduces a 'Bag-of-Experts' model for label-free prediction of multiple organelles across transmitted-light microscopy images, showing generalizability across imaging conditions.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Automated Xeno-Free Chondrogenic Differentiation from Human Embryonic Stem Cells: Enhancing Efficiency and Ensuring High-Quality Mass Production

This study develops an automated xeno-free system for efficient chondrogenic differentiation of human embryonic stem cells, producing high-quality cartilage suitable for clinical applications.

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

The differential effect of optogenetic serotonergic manipulation on sustained motor actions and stationary waiting for future rewards in mice

This study investigates how optogenetic manipulation of DRN serotonergic neurons affects motor actions and waiting behavior in mice during reward tasks, finding distinct effects on sustained actions versus stationary waiting.

Synthetic organelles enable protein purification in a single operation

This paper introduces PandaPure, a synthetic organelle-based method for protein purification that simplifies and enhances the process in Escherichia coli.

Denitrification genotypes of endospore-forming Bacillota

The paper identifies denitrification genotypes in Bacillota using HMMs and genome-resolved metagenomics, finding complete denitrification potential in several MAGs and 17 genera.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

Urea amidolyase as the enzyme for urea utilization in algae: functional display in Chlamydomonas reinhardtii and evolution in algae

This study identifies urea amidolyase (UAD) as the key enzyme for urea utilization in algae, showing its functional importance and evolutionary distribution in Chlamydomonas reinhardtii.