Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice.
S. M. Lee, J. Muratalla, S. Karimi, A. Diaz-Ruiz, D. Frutos, G. Guzman, B. Ramos-Molina, J. Cordoba-Chacon
This study shows that hepatocyte PPARγ contributes to NASH progression in obese mice and is linked to methionine metabolism and fibrosis.
bioRxiv · Jun 6, 2022Physiology