Thiazides induce glucose intolerance through inhibition of mitochondrial carbonic anhydrase 5b in β-cells
P. Kucharczyk, G. Albano, C. Deisl, S. Wueest, D. Konrad, D. G. Fuster
This study identifies mitochondrial carbonic anhydrase 5b (CA5b) as the molecular target of thiazides, showing its inhibition leads to reduced insulin secretion and glucose intolerance in β-cells.
bioRxiv · Mar 23, 2022 · PreprintPhysiology