c-Jun Overexpressing CAR-T Cells are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity
R. C. Lynn, E. W. Weber, D. Gennert, E. Sotillo, P. Xu, Z. Good, H. Anbunathan, R. Jones, V. Tieu, J. Granja, C. DeBourcy, R. Majzner, A. Satpathy, S. R. Quake, H. Chang, C. L. Mackall
This study shows that overexpressing c-Jun in CAR-T cells reduces exhaustion and improves antitumor activity in vivo.
bioRxiv · May 29, 2019 · PreprintImmunology