H. Chang

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir

This study identifies TAC3 and its homologues as transcriptional co-activators that regulate age-dependent floral transition by modulating miR156 expression in Arabidopsis and Chinese fir.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

De novo multi-mechanism antimicrobial peptide design via multimodal deep learning

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

Non-antibiotic drugs break colonization resistance against pathogenic Gammaproteobacteria

The paper tests non-antibiotic drugs' effects on gut microbiome composition and finds some increase Salmonella abundance, potentially increasing infection risk.

Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.

Optimal Sampling Rate for 3D Single Molecule Localization

This study evaluates how different PSF shapes affect 3D localization accuracy under varying sampling rates and noise conditions, identifying optimal pixel sizes for each PSF.

Sulfasalazine promotes myogenic differentiation via increasing of fast myosin heavy chain isoforms

This study shows sulfasalazine promotes myogenic differentiation by increasing fast myosin heavy chain isoforms through a metabolic shift to glycolysis in C2C12 myoblasts and improves muscle function in aged and injured mice.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

This study identifies MECOM, PAX8, SOX17, and WT1 as master regulators in HGSC, showing their rewired cistromes and tumor-specific inhibition potential.

Glutathione supports lipid abundance in vivo

This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.

Increased ozone levels disrupt insect sexual communication

This study shows that increased ozone levels oxidize male-specific pheromones in Drosophila melanogaster, reducing pheromone amounts and altering sexual recognition.

Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.

Deep learning in human neurons predicts mechanistic subtypes of Parkinson's

This study uses deep learning on patient-derived neurons to predict Parkinson's disease subtypes with high accuracy, highlighting mitochondrial and lysosomal features as key predictors.

Divergent clonal differentiation trajectories of T cell exhaustion

This study identifies divergent clonal differentiation trajectories of T cell exhaustion during chronic viral infection, showing that TCR signal strength determines terminal or KLR Tex fates.

Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

The Mettl3 epitranscriptomic writer amplifies p53 stress responses

This paper identifies Mettl3 as a p53-interacting protein that stabilizes p53 and enhances its tumor suppressive functions through both protein stabilization and m6A modification of p53 pathway transcripts.

Large-scale miRNA-Target Data Analysis to Discover miRNA Co-regulation Network of Abiotic Stress Tolerance in Soybeans

The paper uses computational methods to predict miRNA-target regulatory modules in soybeans under abiotic stress and identifies stress-related modules with gene ontology enrichment.

Structure-Function in Helical Cardiac Musculature Using Additive Textile Manufacturing

This study uses additive textile manufacturing to create helically aligned cardiac muscle models, showing improved mechanical function compared to circumferential models.

Three-dimensional residual channel attention networks denoise and sharpen fluorescence microscopy image volumes

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

This study shows that LKB1 inactivation alters chromatin accessibility, promoting metastatic progression in lung cancer through SOX17 activation.

Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection.

The paper profiles early chromatin accessibility in human neutrophils challenged with pathogens and TLR ligands, identifying challenge-specific epigenomic responses and gene regulation mechanisms.

Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation

The paper uses live cell imaging to show clathrin-coated pits develop curvature early without requiring a flat-to-curved transition.

Predicting master transcription factors from pan-cancer expression data

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

Establishment of the trans-resveratrol-induced mouse pulmonary fibrosis model and its comparison with the bleomycin-induced model

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

Differential protein metabolism and regeneration in hypertrophic diaphragm and atrophic gastrocnemius muscles in hibernating Daurian ground squirrels

This study compares protein metabolism and regeneration in diaphragm and gastrocnemius muscles of hibernating and summer-active Daurian ground squirrels, finding distinct regulatory patterns contributing to hypertrophy and atrophy.

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

c-Jun Overexpressing CAR-T Cells are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity

This study shows that overexpressing c-Jun in CAR-T cells reduces exhaustion and improves antitumor activity in vivo.

Genome-Wide Association Analysis Identifies Genetic Correlates of Immune Infiltrates in Solid Tumors.

This study identifies genetic correlates of immune infiltrates in solid tumors using genome-wide association analysis across 40 cancer cohorts.