P. Xu

Metabolomics profiling reveals association of fermented herbal feed additive, growth performance and gut microbiota in piglets

This study shows that fermented Chinese medicine (FCM) improves piglet growth and health by increasing lactic acid and propionic acid levels and altering gut microbiota composition.

Experimental evolution of gene essentiality in bacteria

The paper generates essential gene deletion mutants in Streptococcus sanguinis and identifies suppressor mutations through experimental evolution, revealing new gene and pathway relationships.

A novel infective endocarditis virulence factor related to multiple functions for bacterial survival in blood was discovered in Streptococcus sanguinis

This study identifies SSA_0451 as a novel virulence factor in Streptococcus sanguinis that enhances survival in blood by mitigating oxidative and environmental stress.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migration

This study identifies MARK2 as a regulator of Golgi reorientation during cell migration by phosphorylating CAMSAP2 at serine 835, affecting its interaction with USO1.

Characterizing interactions of ER resident proteins in situ through the YST-PPI method

The paper introduces YST-PPI, a method to study ER resident protein interactions in situ, identifies 74 protein pairs, and highlights Lhs1p's role in regulating these interactions.

Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased degradation of cell surface proteins

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

EI24-RTRAF interaction represses Nox4 translation, vital for redox balance and insulin production

The paper identifies EI24-RTRAF interaction as a regulator of Nox4 translation, maintaining redox balance and insulin production in pancreatic beta cells.

A precise IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean

This paper introduces an IDMS-based LC-MS/MS method for precise quantification of phytohemagglutinin in common beans, showing high linearity, sensitivity, recovery, and repeatability.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

Alasemenia, the earliest ovule with three wings and without cupule

The paper describes a new Devonian ovule, Alasemenia tria, with three wings and no cupule, suggesting early evolution of wind dispersal mechanisms in seed plants.

Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells

The paper investigates the interaction of VPS13A with XK at ER-PM contacts in K562 cells during erythroid differentiation, showing it requires a permissive state dependent on cell type and functional state.

Engineered CD47 protects T cells for enhanced antitumor immunity

This paper engineers a CD47 variant to protect T cells from macrophage clearance, enhancing antitumor efficacy by combining T cell and macrophage activation.

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

Reprogramming a high robust Geobacillus thermoglucosidasius for efficient synthesis of polymer-grade lactic acid under extremely high temperature (60℃)

This study reprograms Geobacillus thermoglucosidasius to produce high-purity lactic acid at 60°C using rational and semi-rational design strategies, achieving high yield and productivity.

Enriched zones of embedded ribonucleotides are associated with DNA replication and coding sequences in the human mitochondrial genome

The paper identifies rNMP-enriched zones in human mtDNA linked to replication and coding sequences using ribose-seq across six cell types.

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

Measuring chondrocyte viability of articular cartilage based on label-free two-photon microscopy and deep learning image analysis

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Comparative genomic analysis between Leonurus japonicus and Leonurus sibiricus

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

Coupled functional physiological phenotyping and simulation model to estimate dynamic water use efficiency and infer transpiration sensitivity traits

Structural Genomics of the Human Dopamine Receptor System

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

Understanding water conservation vs. profligation traits in vegetable legumes through a physio-transcriptomic-functional approach

This study compares water use strategies in soybean and cowpea under drought using phenomic and transcriptomic analyses, identifying gene networks and regulatory mechanisms underlying their contrasting responses.

SOGO-SOFI, light-modulated super-resolution optical fluctuation imaging using only 20 raw frames for high-fidelity reconstruction

This paper introduces SOGO-SOFI, a light-modulated super-resolution imaging technique that uses only 20 frames for high-fidelity reconstruction, achieving higher temporal resolution and reduced artifacts compared to pcSOFI.

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

This study identifies the Mediator kinase module as a regulator of T cell differentiation and shows that its inhibition enhances effector T cell potency.