PhysiologybioRxiv
Conserved cysteines in titin sustain the mechanical function of cardiomyocytes
E. Herrero-Galan, F. Dominguez, I. Martinez-Martin…·Aleg
The paper identifies that mutations in conserved titin cysteines disrupt mechanoredox control, leading to dilated cardiomyopathy in humans.
DOI 10.1016/j.redox.2022.102306