Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice
N. Ahlskog, D. Hayler, A. Krueger, S. Kubinski, P. Claus, R. J. Yanez-Munoz, M. Bowerman
This study tests if muscle-specific Klf15 overexpression via AAV8 improves SMA mouse survival, finding limited efficacy in some models.
bioRxiv · Jul 30, 2019Pathology