Author

M. Bowerman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

N. Ahlskog· 3 shared P. Claus· 3 shared A. Bhomra· 2 shared E. McCallion· 2 shared E. R. Sutton· 2 shared G. Hazell· 2 shared J. M. Hoolachan· 2 shared M. J. Wood· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPathology

N. Ahlskog

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Author profile →

5 papers

Recent·Most cited

Exercise and disease state influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model

G. Hazell, N. Ahlskog, E. R. Sutton, M. Okoh, J. M. Hoolachan, T. Scaife, S. Iqbal, E. McCallion, A. Bhomra, A. J. Kordala, F. Scamps, C. Raoul, M. J. Wood, M. Bowerman

This study shows that Fn14-depletion improves survival and muscle pathology in SOD1G93A ALS mice, but only when combined with exercise.

bioRxiv · Jul 5, 2024 · PreprintPathology

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models

J. M. Hoolachan, E. McCallion, E. R. Sutton, O. Cetin, P. Pacheco-Torres, M. Dimitriadi, M. Okoh, L. M. Walter, P. Claus, M. J. Wood, D. P. Tonge, M. Bowerman

The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.

bioRxiv · Jun 14, 2023Pathology

Dysregulation of the Tweak/Fn14 pathway in skeletal muscle of spinal muscular atrophy mice

K. E. Meijboom, E. McFall, D. Anthony, B. Edwards, S. Kubinski, G. Hazell, N. Ahlskog, P. Claus, K. E. Davies, R. Kothary, M. Wood, M. Bowerman

This study investigates the TWEAK/Fn14 pathway dysregulation in SMA mouse models and shows its role in muscle pathology and potential therapeutic intervention.

Skeletal Muscle · Dec 1, 2022Peer-reviewedPathology

Dystrophin regulates peripheral circadian SRF signalling

C. A. Betts, A. Jagannath, T. van Westering, M. Bowerman, S. Banerjee, J. Meng, M. S. Falzarano, L. Cravo, G. McClorey, K. Meijboom, A. Bhomra, C. Lim, C. Rinaldi, J. Counsell, K. Chwalenia, , M. Wood

This study shows dystrophin loss disrupts the RhoA-actin-SRF pathway, leading to circadian dysregulation in muscle and peripheral tissues.

bioRxiv · Jun 23, 2021 · PreprintCell Biology

Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

N. Ahlskog, D. Hayler, A. Krueger, S. Kubinski, P. Claus, R. J. Yanez-Munoz, M. Bowerman

This study tests if muscle-specific Klf15 overexpression via AAV8 improves SMA mouse survival, finding limited efficacy in some models.

bioRxiv · Jul 30, 2019Pathology