Non-standard viral genome-derived RNA activates TLR3 and type I IFN signaling to induce cDC1-dependent CD8+ T-cell responses during vaccination in mice
D. Fisher, D. Holthausen, C. B. Lopez
This study identifies DDO as a novel adjuvant that activates TLR3 and type I IFN signaling via cDC1s to induce CD8+ T-cell responses in mice during vaccination.
bioRxiv · Jun 9, 2022Immunology