C. B. Lopez

Indiscriminate activities of different Henipavirus polymerase complex proteins allow for efficient minigenome replication in hybrid systems

This paper develops minigenome systems for Nipah and Hendra viruses and shows that their polymerase complex proteins can replicate both minigenomes regardless of origin, suggesting potential targets for antivirals.

Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology

This study shows that Sendai virus persists in lung innate immune cells, leading to chronic lung disease by upregulating antiviral and inflammatory genes.

S RNA Intergenic Deletions Drive Viral Interference during Arenavirus Infections

This study identifies intergenic deletions in arenavirus S RNA that inhibit viral replication and suggests they as targets for antivirals and vaccines.

Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity

This study shows that copy-back viral genomes (cbVGs) induce cellular stress responses, including stress granules and translation inhibition, during RSV and parainfluenza virus infections, which reduce viral protein expression without affecting antiviral immunity.

Non-standard viral genome-derived RNA activates TLR3 and type I IFN signaling to induce cDC1-dependent CD8+ T-cell responses during vaccination in mice

This study identifies DDO as a novel adjuvant that activates TLR3 and type I IFN signaling via cDC1s to induce CD8+ T-cell responses in mice during vaccination.

Accumulation of copy-back viral genomes during respiratory syncytial virus infection is preceded by diversification of the copy-back viral genome population followed by selection

This study shows that host permissiveness to RSV influences the diversification and selection of copy-back viral genomes during infection.

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

The paper identifies viral polymerase complex components L and C as mediators of vRNP interaction with Rab11a-marked recycling endosomes during SeV assembly.

Circadian control of lung inflammation in influenza infection

This study shows that circadian rhythms affect lung inflammation during influenza infection by influencing immune cell composition rather than viral replication.

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

This study shows replication defective viral genomes (DVGs) protect certain cells from death and promote viral persistence by activating a TNF-mediated survival pathway during infection.