D. Fisher

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Non-standard viral genome-derived RNA activates TLR3 and type I IFN signaling to induce cDC1-dependent CD8+ T-cell responses during vaccination in mice

This study identifies DDO as a novel adjuvant that activates TLR3 and type I IFN signaling via cDC1s to induce CD8+ T-cell responses in mice during vaccination.

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

The paper shows CDK8 and CDK19 redundantly regulate the CFTR pathway in intestinal epithelium, leading to mucus accumulation and goblet cell secretion when both are deleted.

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

Single-embryo phosphoproteomics reveals the importance of intrinsic disorder in cell cycle dynamics

The paper uses single-embryo phosphoproteomics to show that phosphorylation of intrinsically disordered proteins by cell cycle kinases drives switch-like mitotic reorganization.

Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after DNA damage-induced G2 arrest

Seeding of outbreaks of COVID-19 by contaminated fresh and frozen food

The paper was withdrawn due to prior regulatory approval issues, and the authors request it not be cited.

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

Antibiotic hypersensitivity signatures identify targets for attack in the Acinetobacter baumannii cell envelope

This study identifies antibiotic hypersensitivity signatures in A. baumannii to discover new targets for attacking the pathogen's cell envelope.

Ki-67 promotes sequential stages of tumourigenesis by enabling cellular plasticity

This study shows Ki-67 enables cellular plasticity across tumourigenesis stages, with knockout inhibiting tumour growth and metastasis through transcriptome remodelling and angiogenesis disruption.

CDK8 and CDK19 kinases have non-redundant oncogenic functions in hepatocellular carcinoma

The paper investigates the roles of CDK8 and CDK19 in hepatocellular carcinoma, finding they are overexpressed and have non-redundant oncogenic functions that interact with TP53.

Dynamic networks of fighting and mating in a wild cricket population

The paper analyzes fighting and mating interactions in wild crickets to show how spatial proximity, individual traits, and social network structure dynamically influence social behavior.

Predictors of colony extinction vary by habitat type in social spiders

The study examines how environmental factors predict colony extinction in social spiders across different habitats, finding that ant attacks and fungal outbreaks are key drivers in deserts and savannas, respectively.

Indirect effects on fitness between individuals that have never met via an extended phenotype

The paper shows that red squirrels' hoarding behavior, an extended phenotype, influences future individuals' fitness and resource acquisition without direct interaction.

Initiation of DNA replication requires actin dynamics and formin activity

The paper shows that actin dynamics and formin activity are essential for DNA replication and nuclear transport in human cells and Xenopus egg extracts.