ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan
Eric K.F. Donahue, Nathaniel L. Hepowit, Brennen Keuchel, Alexandra G. Mulligan, D. J. Johnson, Mark H. Ellisman, Rafael Arrojo e Drigo, Jason A. MacGurn, Kristopher Burkewitz
This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.
bioRxiv · Aug 7, 2024 · PreprintCell Biology