Mark H. Ellisman

This study investigates circadian disruption in Alzheimer's disease using APP/PS1 mice, finding gene expression and connectomic changes in the SCN independent of amyloid beta deposits.

The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

This study shows that blocking fibrin-microglia interactions reduces AD-related brain network dysfunction and behavioral issues in mice.

ColorSTEM improves multicolor electron microscopy by using metal-conjugated DAB to enhance signal and simplify imaging.

The paper identifies AKAP1 as a critical regulator of mitochondrial and synaptic homeostasis in glaucoma, showing its role in neuroprotection and axon regeneration through gene therapy in mouse models.

The paper examines daily structural changes in Drosophila clock neurons using SBEM, revealing rhythmic variations in morphology, synaptic markers, and mitochondrial structure.

The paper investigates how glaucoma-associated Optineurin mutations affect transmitophagy in Xenopus laevis optic nerves, finding increased mitochondrial shedding and degradation by astrocytes.

This study identifies Kirrel3-expressing inhibitory neurons that regulate memory discrimination in mice by inhibiting CA3 neuron activity during memory recall.

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

The paper analyzes dendritic morphology of CO2- and odor-sensing olfactory neurons in Drosophila using electron microscopy, revealing morphological diversity even among homotypic neurons.

The paper maps the endomembrane system of cerebellar Purkinje neurons using electron microscopy, revealing cell-type-specific and subcellular structural organization of organelles.

This paper develops a PEG-doped resin to reduce specimen charging in SBEM, improving imaging quality without sacrificing resolution or physical properties.

This study shows that restoring AIBP expression in glaucomatous retinas protects retinal ganglion cells and reduces neuroinflammation in mouse models.

The paper investigates the synaptic architecture of memory engrams in the mouse hippocampus, revealing that memory acquisition involves expansion of connectomes through multi-synaptic boutons without altering axonal terminals or dendritic spines.

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

This study reveals a unique accessory inner segment in human rod photoreceptors that provides structural support to the outer segment, differing from the classic arrangement seen in other species.

This paper introduces a single objective light-sheet microscope for high-resolution in vivo brain imaging in Drosophila, achieving improved resolution and reduced photobleaching and phototoxicity.

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

The paper investigates whether perineuronal nets (PNNs) stabilize synaptic circuits and engram formation through high-resolution imaging and experimental approaches.

This study shows that AIBP regulates TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease, reducing neuroinflammation and neurodegeneration.

This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.

This paper demonstrates limited-tilt serial section electron tomography for high-resolution 3D mapping of brain circuits and evaluates imaging parameters for connectomic-scale projects.

The paper characterizes ECM/PNN molecules around neurons and introduces a new mouse model for monitoring live ECM dynamics using genetically encoded labeling of HAPLN1.

The paper introduces Fe-TAML, a small molecule peroxidase probe for correlated light and electron microscopy, demonstrating its use in imaging DNA, tagged proteins, and endogenous proteins.

The paper maps synaptic connectivity patterns in the SCN core and shell using EM techniques, showing the shell receives denser mRGC inputs than the core.

The paper tracks single HSPCs in zebrafish using light and electron microscopy to identify a new niche cell type and resolve their ultrastructural interactions.