Author

D. J. Lessner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. E. Dhamad· 3 shared M. Chanderban· 2 shared A. Dhamad· 1 shared A. J. Alverson· 1 shared A. Muniyasamy· 1 shared C. A. Hill· 1 shared J. M. Hoerr· 1 shared J. Saini· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

A. E. Dhamad

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4 papers

Recent·Most cited

The nitrogenase cofactor biogenesis enzyme NifB is essential for the viability of methanogens

J. Saini, A. Dhamad, A. Muniyasamy, A. J. Alverson, D. J. Lessner

This paper shows that NifB is essential for methanogen viability and functions beyond nitrogenase maturation, linking it to nitrogen fixation and methanogenesis.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Vht hydrogenase is required for hydrogen cycling during nitrogen fixation by the non-hydrogenotrophic methanogen Methanosarcina acetivorans.

J. M. Hoerr, A. E. Dhamad, T. M. Deere, M. Chanderban, D. J. Lessner

This study shows that Vht hydrogenase in M. acetivorans recycles H2 produced by nitrogenase during N2 fixation, enabling optimal growth.

bioRxiv · Oct 12, 2021 · PreprintMicrobiology

Methanosarcina acetivorans simultaneously produces molybdenum, vanadium, and iron-only nitrogenases in response to fixed nitrogen and molybdenum depletion

M. Chanderban, C. A. Hill, A. E. Dhamad, D. J. Lessner

This study shows Methanosarcina acetivorans can produce all three nitrogenases (Mo, V, Fe) simultaneously under specific nutrient conditions, revealing tight regulation and potential cross-regulation between them.

bioRxiv · Jun 3, 2021 · PreprintMicrobiology

A CRISPRi-dCas9 system for archaea and its use to examine gene function during nitrogen fixation by Methanosarcina acetivorans.

A. E. Dhamad, D. J. Lessner

This paper develops a CRISPRi-dCas9 system for archaea and demonstrates its use in studying nitrogen fixation in Methanosarcina acetivorans by repressing gene expression.

bioRxiv · Jun 15, 2020Microbiology