Author

J. Saini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Gras· 2 shared B. K. Gautam· 2 shared B. Tinsley· 2 shared E. Benzie· 2 shared E. K. Wagner· 2 shared J. F. Simons· 2 shared J. Leong· 2 shared K. P. Carter· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. Gras

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The nitrogenase cofactor biogenesis enzyme NifB is essential for the viability of methanogens

J. Saini, A. Dhamad, A. Muniyasamy, A. J. Alverson, D. J. Lessner

This paper shows that NifB is essential for methanogen viability and functions beyond nitrogenase maturation, linking it to nitrogen fixation and methanogenesis.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Lack of blocking activity in anti-CTLA-4 antibodies reduces toxicity, but not anti-tumor efficacy

E. L. Stone, K. P. Carter, E. K. Wagner, M. A. Asensio, E. Benzie, Y. Y. Chiang, G. L. Coles, C. Edgar, B. K. Gautam, A. Gras, J. Leong, R. Leong, V. A. Manickam, R. A. Mizrahi, A. Niedecken, , D. S. Johnson

This study shows that anti-CTLA-4 antibodies with reduced checkpoint inhibition have better anti-tumor efficacy and lower toxicity by primarily depleting tumor-infiltrating Tregs via FcR signaling.

bioRxiv · Jul 12, 2021 · PreprintImmunology

Capturing and Recreating Diverse Antibody Repertoires as Multivalent Recombinant Polyclonal Antibody Drugs

S. M. Keating, R. A. Mizrahi, M. S. Adams, M. A. Asensio, E. Benzie, K. P. Carter, Y. Chiang, R. C. Edgar, B. K. Gautam, A. Gras, J. Leong, R. Leong, Y. W. Lim, V. A. Manickam, A. V. Medina-Cucurella, , E Meyer

This paper demonstrates a technology to capture and recreate diverse antibody repertoires as multivalent recombinant drugs, showing applications against SARS-CoV-2, Zika virus, and graft-versus-host disease.

bioRxiv · Aug 5, 2020 · PreprintImmunology