Evolutionary BiologybioRxiv
The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus
H. L. Wells, M. C. Letko, G. Lasso…·S. J. Anthony
This study investigates the evolutionary history of ACE2 usage in sarbecoviruses, showing that ACE2 usage in SARS-CoV-1 and SARS-CoV-2 likely arose through recombination with SARS-CoV-1 relatives, not SARS-CoV-2.
DOI 10.1093/ve/veab007