Author

D. Ladd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Tilunaite· 2 shared C. Soeller· 2 shared V. Rajagopal· 2 shared E. Crampin· 1 shared E. J. Crampin· 1 shared H. Hunt· 1 shared H. L. Roderick· 1 shared H. Roderick· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

A. Tilunaite

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2 papers

Recent·Most cited

IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+

J. Chung, A. Tilunaite, D. Ladd, H. Hunt, C. Soeller, E. J. Crampin, S. Johnston, H. Roderick, V. Rajagopal

The paper develops a mathematical model to show IP3R activity increases Ca2+ sparks by raising dyadic Ca2+ levels, which sensitizes RyRs but reduces JSR Ca2+ availability.

bioRxiv · Aug 13, 2020Biophysics

Detecting RyR clusters with CaCLEAN: influence of spatial distribution and structural heterogeneity

D. Ladd, A. Tilunaite, C. Soeller, H. L. Roderick, E. Crampin, V. Rajagopal

This paper evaluates the performance of the CaCLEAN algorithm in detecting RyR clusters using simulated calcium fluorescence imaging data, showing sensitivity to cluster density and depth.

bioRxiv · Apr 11, 2019Bioengineering