Author

V. Rajagopal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Tilunaite· 2 shared C. Soeller· 2 shared D. Ladd· 2 shared E. Crampin· 2 shared E. Hanssen· 2 shared S. Ghosh· 2 shared A. Hickey· 1 shared A. Hussain· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

A. Tilunaite

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Energy dependence of signalling dynamics and robustness in bacterial two component systems

J. E. Forrest, M. Pan, V. Rajagopal, E. Crampin, M. P. H. Stumpf

This paper models energy flow through two variants of bacterial two-component systems to show how energy availability affects signal sensitivity, noise filtering, and response thresholds.

bioRxiv · Feb 12, 2023 · PreprintBiophysics

Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study

S. Ghosh, G. Guglielmi, I. Orfanidis, F. Spill, A. Hickey, E. Hanssen, V. Rajagopal

This study uses computational modeling to show that disorganized mitochondrial and myofibrillar arrangement in diabetic cardiomyocytes leads to spatial variation in ADP/ATP ratios and increased inorganic phosphate concentration.

bioRxiv · May 22, 2022Cell Biology

Cortical Tension Initiates the Positive Feedback Loop Between E-cadherin and F-actin

Q. Yu, W. R. Holmes, J. P. Thiery, R. B. Luwor, V. Rajagopal

This paper presents a computational model showing cortical tension initiates a positive feedback loop between E-cadherin and F-actin, stabilizing cell-cell adhesion through mechano-chemical interactions.

bioRxiv · Feb 23, 2021Biophysics

IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+

J. Chung, A. Tilunaite, D. Ladd, H. Hunt, C. Soeller, E. J. Crampin, S. Johnston, H. Roderick, V. Rajagopal

The paper develops a mathematical model to show IP3R activity increases Ca2+ sparks by raising dyadic Ca2+ levels, which sensitizes RyRs but reduces JSR Ca2+ availability.

bioRxiv · Aug 13, 2020Biophysics

Detecting RyR clusters with CaCLEAN: influence of spatial distribution and structural heterogeneity

D. Ladd, A. Tilunaite, C. Soeller, H. L. Roderick, E. Crampin, V. Rajagopal

This paper evaluates the performance of the CaCLEAN algorithm in detecting RyR clusters using simulated calcium fluorescence imaging data, showing sensitivity to cluster density and depth.

bioRxiv · Apr 11, 2019Bioengineering

An Automated Workflow for Segmenting Single Adult Cardiac Cells from Large-Volume Serial Block-Face Scanning Electron Microscopy Data

A. Hussain, S. Ghosh, S. Beikoghli Kalkhoran, D. Hausenloy, E. Hanssen, V. Rajagopal

This paper introduces an automated algorithm to segment cardiac cell structures from SBF-SEM data, achieving 97% accuracy and enabling 3D finite element mesh generation for computational physiology studies.

bioRxiv · Jan 4, 2018Bioengineering