Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB
J. Sun, D. LaRock, E. Skowronski, J. M. Kimmey, J. Olson, Z. Jiang, A. O'Donoghue, V. Nizet, C. LaRock
This study identifies that the Pseudomonas aeruginosa protease LasB directly activates IL-1β independently of inflammasomes, contributing to lung inflammation and pathology during infection.
bioRxiv · May 18, 2020 · PreprintMicrobiology