J. Olson

A Method for Electrical Stimulus Artifact Removal Exploiting Neural Refractoriness: Validation by Contrasting Cathodic and Anodic Stimulation

This paper introduces a method to remove electrical stimulus artifacts by exploiting neural refractoriness, showing distinct neural responses to cathodic and anodic stimulation.

Functional genomic analysis of adult and pediatric brain tumor isolates

This study identifies shared and unique gene dependencies between adult and pediatric brain tumor isolates using CRISPR screens and machine learning models.

Sex-biased Yap1 oncogene function

This study shows that Yap1, an oncogene, has sex-biased functions in medulloblastoma progression and immune suppression, with greater impact in males.

FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation, and lethality in glioblastoma and other cancers

This study identifies FBXO42 as essential for preventing mitotic arrest and cell death in glioblastoma and other cancers by suppressing chromosome-microtubule dynamics disruption.

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

This study evaluates a nanoparticle vaccine displaying EBV gH/gL, showing it protects humanized mice against lethal EBV challenge, while monomeric gH/gL does not.

Repurposed Drugs Block Toxin-Driven Platelet Clearance by the Hepatic Ashwell-Morell Receptor to Clear Staphylococcus aureus Bacteremia

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

Building a virtual summer research experience in cancer for high school and early undergraduate students: lessons from the COVID-19 pandemic

This paper describes a virtual summer research program in cancer for high school and early undergraduate students during the COVID-19 pandemic and evaluates its outcomes.

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.

Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB

This study identifies that the Pseudomonas aeruginosa protease LasB directly activates IL-1β independently of inflammasomes, contributing to lung inflammation and pathology during infection.

Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata

This study evaluates conjugated linoleic acid as an insecticide against Colorado potato beetles, finding increased larval mortality and reduced egg viability.