J. Sun

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Seasonal influenza A virus lineages exhibit divergent abilities to antagonize interferon induction and signaling

This study compares the ability of seasonal H1N1 and H3N2 influenza A viruses to antagonize interferon induction and signaling at the single-cell level, finding differences in their IFN antagonism potential.

Neuronal GPCR NMUR-1 regulates energy homeostasis in response to pathogen infection

This study shows that NMUR-1 in C. elegans neurons controls energy homeostasis and innate immune specificity through ATP regulation in response to bacterial pathogens.

Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

This study identifies microbial pseudomorphs as the earliest three-dimensional body fossils of segmented bilaterians from the basal Cambrian, revealing a diversified bilaterian world.

The silicon transporters (SITs) gene was found in Synechococcus sp. XM24

This study identifies and characterizes potential silicon transporters (SITs) in Synechococcus sp. XM24 under silicate-depleted conditions.

Perfringolysin O pore-forming complexes are predominantly integral multiples of six subunits

The paper investigates the structural composition of Perfringolysin O (PFO) complexes, finding that they are predominantly hexameric and built from hexameric sub-complexes.

Imaging of porphyrin-specific fluorescence in pathogenic bacteria in vitro using a wearable, hands-free system

The paper demonstrates the use of a wearable fluorescence imaging system to detect porphyrin-specific fluorescence in pathogenic bacteria, showing its effectiveness in identifying bacterial strains associated with infections.

Silicification of Cyanobacteria

This study compares silicification mechanisms in cyanobacteria and diatoms, finding similar proteins but suggesting cyanobacteria may have an earlier but less efficient silicon accumulation mechanism.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

RAG suppresses group 2 innate lymphoid cells

This study shows that RAG suppresses group 2 innate lymphoid cells (ILC2s), affecting their cytokine production and contributing to inflammation in atopic dermatitis.

The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.

This study shows methylglyoxal, a glycolytic metabolite, covalently inactivates the NLRP3 inflammasome by forming crosslinks, thereby reducing inflammation.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

HNF&alpha is a target of the Wnt/beta-catenin pathway and regulates colorectal carcinogenesis

This study shows HNF4 is upregulated in colorectal cancer and promotes tumorigenesis by being activated by the Wnt/β-catenin pathway.

Mutability and hypermutation antagonize immunoglobulin codon optimality

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink

This study identifies shallow-water chemosymbiotic clams as a significant, previously overlooked carbon sink in the Yellow Sea, contributing 43% of the region's sedimental carbon burial.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions

This study shows that lack of IFN-γ signaling leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions, highlighting its critical role in immune defense.

In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia

This study shows that cardiac dysfunction in septic shock occurs without high catecholamine levels or microvascular ischemia, and epinephrine infusions cause prolonged microvascular perfusion issues.

Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock

This study uses cardiac magnetic resonance imaging in a canine sepsis model to show that ventricular wall edema and structural changes, not preload or afterload, explain differences in cardiac function and survival outcomes during sepsis.

Genomic insights into photosymbiotic evolution in Tridacna squamosa

This study presents the first complete genome of Tridacna squamosa and integrates multi-omics data to uncover molecular mechanisms underlying photosymbiosis with dinoflagellates.

The EGF/EGFR-YAP1/TEAD2 axis-mediated BRAF inhibitor vemurafenib resistance upregulates STIM1 in melanoma

This study identifies the EGF/EGFR-YAP1/TEAD2 axis as a mechanism by which vemurafenib resistance upregulates STIM1 in melanoma.

Screening for metastasis-related genes in mouse melanoma cells through sequential tail vein injection

This study screens for metastasis-related genes in mouse melanoma cells using sequential tail vein injection and identifies differentially expressed genes associated with metastasis.

PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

This study identifies PI3Kγ as a regulator of neutrophil extracellular trap formation in abdominal aortic aneurysm via noncanonical pyroptosis, showing its inhibition reduces inflammation and ameliorates AAA.