Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.
G. Padalino, C. A. Celatka, H. Y. Rienhoff, J. H. Kalin, P. A. Cole, D. Lassalle, C. Grunau, I. W. Chalmers, A. Brancale, K. F. Hoffmann
This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.
bioRxiv · Sep 17, 2020 · PreprintMicrobiology