Author

C. Grunau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Evolutionary Biology· 2 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:DNA methylation· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Cosseau· 4 shared C. Chaparro· 3 shared J. Vidal-Dupiol· 2 shared M. D. Sow· 2 shared N. Luviano· 2 shared A. Brancale· 1 shared A. Delaunay· 1 shared A. Minoda· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersEcology

C. Cosseau

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Epigenetic variation causes heritable variation in complex traits in the mollusk Biomphalaria glabrata, vector of the human parasite Schistosoma mansoni

N. Luviano, M. Lopez, F. Gawehns, B. Haegeman, P. Mouginot, C. Chaparro, P. B. Arimondo, B. Pujol, D. Pouzol, C. Cosseau, C. Grunau

The paper shows that epigenetic variation in Biomphalaria glabrata affects heritable complex traits like fecundity and resistance to Schistosoma mansoni.

bioRxiv · Jul 8, 2023 · PreprintEcology

Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS)

J. Gawra, A. Valdivieso, F. Roux, M. Laporte, J. de Lorgeril, Y. Gueguen, M. Saccas, J.-M. Escoubas, C. Montagnani, D. Destoumieux-Garzon, F. Lagarde, M. Leroy, P. Haffner, B. Petton, C. Cosseau, , J. Vidal-Dupiol

This study shows that both genetic and epigenetic variations contribute to rapid adaptation of oyster populations to POMS, with epigenetic factors explaining a significant portion of phenotypic variation.

bioRxiv · Mar 9, 2023Evolutionary Biology

Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.

G. Padalino, C. A. Celatka, H. Y. Rienhoff, J. H. Kalin, P. A. Cole, D. Lassalle, C. Grunau, I. W. Chalmers, A. Brancale, K. F. Hoffmann

This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology

Hypomethylated poplars show higher tolerance to water deficit and highlight a dual role for DNA methylation in shoot meristem: regulation of stress response and genome integrity

M. D. Sow, A.-L. Le Gac, R. Fichot, S. Lanciano, A. Delaunay, I. Le Jan, M.-C. Lesage-Descauses, S. Citerne, J. Caius, V. Brunaud, L. Soubigou-Taconnat, H. Cochard, V. Segura, C. Chaparro, C. Grunau, , S. Maury

This study shows hypomethylated poplars are more drought-tolerant and reveals DNA methylation's role in stress response and genome integrity in shoot meristems.

bioRxiv · Apr 16, 2020 · PreprintPlant Biology

Chromatin structure changes in Daphnia populations upon exposure to environmental cues - or - The discovery of Wolterecks \"Matrix\"

R. de Carvalho Augusto, A. Minoda, O. Rey, C. Cosseau, C. Chaparro, J. Vidal-Dupiol, J.-F. Allienne, D. Duval, S. Pinaud, S. Tonges, R. Andriantsoa, E. Luquet, F. Aubret, M. D. Sow, P. David, , C. Grunau

The paper revisits Woltereck's Matrix hypothesis by showing chromatin structure changes in Daphnia exposed to environmental cues using a new ATAC-seq method.

bioRxiv · Oct 30, 2019 · PreprintEvolutionary Biology

A simple Dot Blot Assay for population scale screening of DNA methylation

N. Luviano, S. Diaz-Palma, C. Cosseau, C. Grunau

The paper validates a dot blot assay for measuring DNA methylation in Biomphalaria glabrata, showing it is cost-effective, requires less DNA, and allows high-throughput screening compared to ELISA.

bioRxiv · Nov 6, 2018 · PreprintEcology