Inducible mucosa-like differentiation of head and neck cancer cells drives the epigenetically determined loss of cell malignancy
F. Oppel, S. Gendreizig, L. Martinez-Ruiz, J. Florido, A. Lopez-Rodriguez, H. Pabla, L. Loganathan, L. Hose, P. Kuehnel, P. Schmidt, M. Schuermann, J. M. Neumann, F. Viyof Ful, L. U. Scholtz, D. Ligum, , H. Sudhoff
This study shows that HNSCC cells can differentiate into non-malignant cells, losing their tumor-initiating potential and expressing KRT17, suggesting differentiation as a therapeutic target.
bioRxiv · Jun 30, 2023 · PreprintCancer Biology