P. Schmidt

Continuously fluctuating selection reveals extreme granularity and parallelism of adaptive tracking

The paper tracks adaptive genetic changes in Drosophila melanogaster under fluctuating selection pressures, revealing rapid, parallel genomic responses and predictable selection targets over time.

Inducible mucosa-like differentiation of head and neck cancer cells drives the epigenetically determined loss of cell malignancy

This study shows that HNSCC cells can differentiate into non-malignant cells, losing their tumor-initiating potential and expressing KRT17, suggesting differentiation as a therapeutic target.

An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation

This study investigates the population genomics of an inversion polymorphism in Drosophila melanogaster across four continents, finding evidence of balancing selection and climate-driven distribution patterns.

Evolution Tracks Multiple Timescales at Once

The paper shows that adaptation in Drosophila melanogaster occurs across multiple timescales, with both immediate and lagged responses shaping genomic change.

Elemental stoichiometry and insect chill tolerance: Evolved and plastic changes in organismal Na+ and K+ content in Drosophila

This study examines how acclimation and adaptation affect chill tolerance and elemental stoichiometry in Drosophila, finding acclimation has a greater impact than adaptation.

Observation of a single protein by ultrafast X-ray diffraction

The paper demonstrates the first X-ray diffraction pattern from a single protein, Escherichia coli GroEL, showing the feasibility of ultrafast imaging of single proteins.

Direct observation of adaptive tracking on ecological timescales in Drosophila

The paper tracks phenotypic and genomic adaptation in Drosophila over ten generations, showing rapid and dynamic responses to environmental change.

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

Wild flies hedge their thermal preference bets in response to seasonal fluctuations

The paper tests if thermal preference variation in Drosophila melanogaster reflects a bet-hedging strategy across regions and finds evidence supporting this evolutionary strategy.

Robust scan synchronized force-fluorescence imaging.

The paper introduces a synchronized AFM-confocal fluorescence microscope platform to visualize force-induced changes in fluorescent protein distribution in live cells.

Genomic analysis of European Drosophila populations reveals major longitudinal structure, continent-wide selection, and unknown DNA viruses

The paper analyzes genomic variation in European Drosophila populations, revealing longitudinal structure, continent-wide selection, and new DNA viruses.

Accurate allele frequencies from ultra-low coverage pool-seq samples in evolve-and-resequence experiments

This paper introduces a method to accurately estimate allele frequencies from low-coverage pool-seq data in evolve-and-resequence experiments using haplotype inference.

A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila

This study examines how natural variants in the foxo gene, part of the insulin signaling pathway, affect life-history traits in Drosophila across different environmental conditions.

Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster

This study shows that allelic variation at foxo affects body size and starvation tolerance in Drosophila melanogaster, mirroring latitudinal patterns in natural populations.