Cancer BiologybioRxivPreprint
Inducible mucosa-like differentiation of head and neck cancer cells drives the epigenetically determined loss of cell malignancy
F. Oppel, S. Gendreizig, L. Martinez-Ruiz…·H. Sudhoff
This study shows that HNSCC cells can differentiate into non-malignant cells, losing their tumor-initiating potential and expressing KRT17, suggesting differentiation as a therapeutic target.
DOI 10.1101/2023.06.30.547265