Author

D. Linehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Ye· 2 shared S. A. Gerber· 2 shared A. Awada· 1 shared A. Jones· 1 shared A. L. Hughson· 1 shared B. Mills· 1 shared B. N. Mills· 1 shared C. A. Beck· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

J. Ye

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer

A. L. Hughson, G. Hannon, N. A. Salama, T. G. Vrooman, C. A. Stockwell, B. N. Mills, J. Garrett-Larsen, H. Qui, R. Katerji, L. Benoodt, C. J. Johnston, J. D. Murphy, E. Kruger, J. Ye, N. W. Gavras, , S. A. Gerber

This paper demonstrates a combination treatment of SBRT and IL-12 mRNA in murine pancreatic tumors, achieving cures in both primary and metastatic models by enhancing T cell responses.

bioRxiv · Oct 30, 2023 · PreprintCancer Biology

Dual Energy X-ray Absorptiometry (DEXA) as a Longitudinal Outcome Measure of Cancer-Related Muscle Wasting in Mice

C. L. Cole, D. Robinson, J. Ye, B. Mills, S. A. Gerber, C. A. Beck, E. M. Schwarz, D. Linehan

This study validates DEXA as a longitudinal measure of lean body mass and skeletal muscle wasting in a PDAC mouse model.

bioRxiv · Mar 9, 2020Cancer Biology

Septins disruption controls tumor growth and enhances efficacy of Herceptin

R. K. Singh, K. K. Kim, N. Khazan, R. B. Rowswell_Turner, C. Laggner, A. Jones, P. Srivastava, V. Hovanesian, L. Lamere, T. Conley, R. Pandita, C. Baker, J. R. Myers, E. Prichett, A. Awada, , R. Moore

The paper develops UR214-9, a compound that disrupts septin filaments in cancer cells, inhibiting growth of HER2+ tumors and enhancing Herceptin efficacy.

bioRxiv · Feb 19, 2020 · PreprintCancer Biology