J. Ye

High-throughput drug screening for inhibition of influenza A virus infection based on human SIRT1 promoter and Genipin suppressing influenza A virus by activation of AMPK-SIRT1-PGC-1α signaling pathway

This study identifies Genipin and its derivatives as inhibitors of influenza A virus replication by activating the AMPK-SIRT1-PGC-1α signaling pathway and altering metabolic reprogramming.

Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling

This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.

Mitochondrial Raf1 Regulates Glutamine Catabolism

This paper identifies Raf1 within mitochondria where it interacts with GLS to regulate glutamine catabolism and tumorigenesis, independent of MAPK signaling.

Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma

Viral Syncytia Evolve to Resist Interferon

This study shows that SARS-CoV-2 syncytia reduce interferon and antibody effectiveness, explaining the evolution of fusogenic viral variants.

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.

Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer

This paper demonstrates a combination treatment of SBRT and IL-12 mRNA in murine pancreatic tumors, achieving cures in both primary and metastatic models by enhancing T cell responses.

Quantifiable TCR repertoire changes in pre-diagnostic blood specimens among high-grade ovarian cancer patients

The paper analyzes TCR repertoires in blood samples of ovarian cancer patients and controls to identify early detectable immune signatures for high-grade ovarian cancer.

Spatial profiling of ovarian clear cell carcinoma reveals immune-hot features

This study uses spatial profiling to identify immune-hot features in early-stage ovarian clear cell carcinoma that correlate with recurrence.

Butyrate Protects against SARS-CoV-2-induced Tissue Damage in Golden Hamsters.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Improved Genome Editing by an Engineered CRISPR-Cas12a

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

SARS-CoV-2 S protein antagonizes type I interferon downstream signal pathway through interacting and attenuating phosphorylation of STAT1/STAT2

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model

The study compares the effects of a Mediterranean-like fat blend to other diets in Muc2-/- mice, finding it reduces colitis severity and promotes beneficial gut microbes.

Genomic analysis of population structure, antimicrobial resistance, and virulent factors of methicillin-resistant Macrococcus caseolyticus in global lineages

This study analyzes methicillin-resistant M. caseolyticus isolates from retail meat and GenBank, revealing geographic lineage distribution, antimicrobial resistance, virulence factors, and morphological differences.

An enzyme-based system for the extraction of small extracellular vesicles from plants

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

Comprehensive RNA-Seq Reveals Molecular Changes in Kidney Malignancy Among People Living with HIV

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

This study shows that Zika virus causes placental pyroptosis via GSDME activation, leading to adverse fetal outcomes.

Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

Serine Starvation Silences Estrogen Receptor Signaling through Histone Hypoacetylation

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human.

The paper develops a bioinformatic pipeline to analyze scRNA-seq data and identifies intermediate cell states and differentiation stages in the hematopoietic stem cell regulatory microenvironment, revealing conservation between mouse and human.

Endogenous RNA editing of a nuclear gene BOSS triggers flowering in tomato

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.