C. Baker

Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19

The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.

Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.

The paper examines antibody responses to S. pyogenes antigens in individuals with and without pharyngitis, finding differences in IgG and IgA levels and correlations with prior immunity.

Circadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment

This study shows that the tumor microenvironment alters macrophage circadian rhythms, affecting tumorigenesis and macrophage function.

Bioinformatic and Experimental Characterization of the RBM15 RNA Binding Protein

This study characterizes RBM15's RNA binding mechanism through bioinformatics and experiments, showing it interacts with stem-loop RNA motifs via RRMs 2 and 3.

Metabolomic, photoprotective, and photosynthetic acclimatory responses to post-flowering drought in sorghum

The paper investigates drought tolerance in sorghum by analyzing metabolomic, physiological, and transcriptomic responses to post-flowering drought in two genotypes.

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

Slippery when wet: cross-species transmission of divergent coronaviruses in bony and jawless fish and the evolutionary history of the Coronaviridae

The paper identifies divergent coronaviruses in bony and jawless fish, revealing cross-species transmission and distinct evolutionary patterns within the Coronaviridae family.

Sequence evaluation and comparative analysis of novel assays for intact proviral HIV-1 DNA

This study compares two novel assays, IPDA and Q4PCR, for measuring intact HIV proviral DNA in ART-suppressed individuals, finding significant differences in their frequency estimates.

Tracking bacterial lineages in complex and dynamic environments with applications to growth control and persistence

The paper develops a platform to track bacterial lineages during growth and shows changes in growth modes and cell size distribution across exponential, stationary, and post-stationary phases in Escherichia coli and Bacillus subtilis.

Septins disruption controls tumor growth and enhances efficacy of Herceptin

The paper develops UR214-9, a compound that disrupts septin filaments in cancer cells, inhibiting growth of HER2+ tumors and enhancing Herceptin efficacy.