How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization
T. M. Gemeinhardt, R. M. Regy, T. M. Phan, N. Pal, J. Sharma, O. Senkovich, A. J. Mendiola, H. J. Ledterman, A. Henrickson, D. Lopes, U. Kapoor, A. Bihani, D. Sihou, Y. C. Kim, D. Jeruzalmi, , N. J. Francis
The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.
bioRxiv · Oct 26, 2023Biochemistry