Priming Is Dispensable For NLRP3 Inflammasome Activation In Human Monocytes
A. Gritsenko, S. Yu, F. Martin-Sanchez, I. Diaz del Olmo, E.-M. Nichols, D. M. Davis, D. Brough, G. Lopez-Castejon
This study shows that the priming step is not required for NLRP3 inflammasome activation in human monocytes, as nigericin and IL-37 can trigger caspase-1 activation and cytokine release without prior priming.
Frontiers in Immunology · Sep 30, 2020Peer-reviewedImmunology