Author

G. Lopez-Castejon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:multiple species· 1

Frequent Co-Authors

D. Brough· 4 shared F. Martin-Sanchez· 3 shared C. Hoyle· 2 shared H. Bennett· 2 shared R. Wellens· 2 shared A. Adamson· 1 shared A. D. Adamson· 1 shared A. Gritsenko· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

D. Brough

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pyroptosis leads to loss of centrosomal integrity in macrophages

S. Bai, F. Martin-Sanchez, D. Brough, G. Lopez-Castejon

This study shows that NLRP3 inflammasome activation in macrophages leads to loss of centrosomal scaffold protein PCNT, affecting centrosome structure and potentially contributing to inflammatory disease pathogenesis.

bioRxiv · Nov 22, 2023 · PreprintImmunology

Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function

R. Wellens, V. S. Tapia, H. Bennett, A. Adamson, J. Rivers-Auty, J. P. Green, G. Lopez-Castejon, D. Brough, C. Hoyle

The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.

bioRxiv · Jun 26, 2023Immunology

NLRP3 activation in response to disrupted endocytic traffic

B. Lee, C. Hoyle, J. Green, R. Wellens, F. Martin-Sanchez, D. Williams, P. Seoane, H. Bennett, A. D. Adamson, G. Lopez-Castejon, M. Lowe, D. Brough

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

bioRxiv · Sep 15, 2021Immunology

Priming Is Dispensable For NLRP3 Inflammasome Activation In Human Monocytes

A. Gritsenko, S. Yu, F. Martin-Sanchez, I. Diaz del Olmo, E.-M. Nichols, D. M. Davis, D. Brough, G. Lopez-Castejon

This study shows that the priming step is not required for NLRP3 inflammasome activation in human monocytes, as nigericin and IL-37 can trigger caspase-1 activation and cytokine release without prior priming.

Frontiers in Immunology · Sep 30, 2020Peer-reviewedImmunology