D. Brough

Cell volume tunes macrophage innate inflammatory responses through promoting type I interferon signalling.

This study shows that cell volume changes in macrophages enhance type I interferon signaling and inflammation through a DNA- and STING-dependent mechanism.

Cerebral ischaemic stroke results in altered mucosal IgA responses and host-commensal microbiota interactions.

This study shows that cerebral ischaemic stroke alters mucosal IgA responses and host-commensal microbiota interactions, leading to changes in intestinal microbiota composition.

High-Dimensional Imaging of Vestibular Schwannoma Reveals Distinctive Immunological Networks Across Histomorphic Niches in NF2-related Schwannomatosis

This study uses imaging mass cytometry to analyze spatial immunological differences in vestibular schwannomas from NF2 SWN patients, revealing niche-dependent T-cell regulation.

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome.

This study shows the NLRP3 inflammasome is crucial for IL-18 production in a murine model of MAS but not for other disease features.

Pyroptosis leads to loss of centrosomal integrity in macrophages

This study shows that NLRP3 inflammasome activation in macrophages leads to loss of centrosomal scaffold protein PCNT, affecting centrosome structure and potentially contributing to inflammatory disease pathogenesis.

Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect outcome

The paper maps myeloid cell spatial organisation in glioblastoma and links it to patient survival.

Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function

The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.

Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

Trends in Subcutaneous Tumour Height and Impact on Measurement Accuracy

This study shows that measuring tumour height improves volume calculation accuracy by 36X compared to using width as a proxy for height in subcutaneous mouse tumours.

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

NLRP3 activation in response to disrupted endocytic traffic

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

Itaconate and fumarate derivatives exert a dual inhibitory effect on canonical NLRP3 activation in macrophages and microglia

This study shows itaconate and fumarate derivatives inhibit both priming and activation of NLRP3 inflammasome in macrophages and microglia, suggesting their therapeutic potential for NLRP3-driven diseases.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

Priming Is Dispensable For NLRP3 Inflammasome Activation In Human Monocytes

This study shows that the priming step is not required for NLRP3 inflammasome activation in human monocytes, as nigericin and IL-37 can trigger caspase-1 activation and cytokine release without prior priming.

Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung

This study shows NLRP3 limits lung neutrophilia and helminth killing in an inflammasome-independent way, while promoting tissue repair.