S. Yu

Molecular Insights into AGS3's Role in Spindle Orientation: A Biochemical Perspective

This study investigates AGS3's role in spindle orientation, showing it differs from LGN due to structural differences and regulatory interactions with Insc.

An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth

This paper identifies a phosphorylation mechanism controlled by the ERECTA receptor and auxin signaling that regulates stem cell activity and vascular cell differentiation in plants.

c-di-GMP modulates ribosome assembly by inhibiting rRNA methylation

This study shows c-di-GMP inhibits rRNA methylation by binding to RlmI, modulates ribosome assembly, and promotes antibiotic tolerance in E. coli.

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

The paper identifies IL-1β as a factor that inhibits SARS-CoV-2-induced cell-cell fusion by promoting actin bundles, thereby restricting viral transmission.

An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics

The paper identifies a multi-protein complex in PBMCs as a target for ALS therapeutic assembly modulators, showing altered composition in ALS patients and responsiveness to treatment.

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

Rice OsPLATZ3 controls ROS homeostasis by inhibiting ROS-Scavenging Activity during Tapetum Degeneration

This study identifies OsPLATZ3 as a regulator of ROS homeostasis during tapetum degeneration in rice, showing its role in suppressing ROS scavenging and causing male sterility.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

Morroniside promotes skin wound re-epithelialization by facilitating epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin expression

This study shows that morroniside promotes skin wound healing by enhancing epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin and downstream targets.

Macrophages control pathological interferon responses during viral respiratory infection

This study identifies macrophage-derived Oncostatin M as a critical regulator of type I interferon responses during viral respiratory infection, preventing excessive inflammation.

Aerosolized α1 adrenoreceptor antagonism does not affect experimentally induced lung fibrosis in animal models

This study tests if inhaled terazosin, an α1 adrenoreceptor antagonist, reduces lung fibrosis in animal models but finds no significant effect.

Is M1-L121E a good mimic on microbial rhodopsin? A viewpoint from excited-state dynamics

This paper investigates the excited-state dynamics of a microbial rhodopsin mimic, M1-L121E, and finds it captures key features but shows distinct differences in photoreaction dynamics compared to natural rhodopsin.

Epigenetic Reshaping through Damage: Promoting Cell Fate Transition by BrdU and IdU Incorporation

The paper investigates how BrdU and IdU incorporation through DNA damage repair induces epigenetic changes that promote cell fate transition.

BrrRCO, encoding a homeobox protein, is involved in leaf lobe development in Brassica rapa

This study identifies BrrRCO, a HD-Zip transcription factor, as a key gene regulating leaf lobe development in Brassica rapa, with cis-regulatory variations affecting its function and leaf shape.

SMU_1361c regulates the oxidative stress response of Streptococcus mutans

This study identifies SMU_1361c as a transcriptional repressor regulating oxidative stress response in Streptococcus mutans, showing its role in pathogenesis and potential for therapeutic development.

An Interleukin 9-Zbtb18 axis promotes germinal center development of memory B cells

This study identifies an Il-9-Zbtb18 axis that promotes the development of memory B cells from germinal centers by regulating cell cycle, survival, and GC exit.

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

This study shows that pre-existing CMV immunity in nonhuman primates reduces placental transmission and fetal loss during reinfection compared to primary infection.

A small number of human lineage mutations regulated RNA-protein binding of conserved genes and promoted human evolution

The paper uses deep learning to predict how human lineage mutations affect RNA-protein binding, finding that a small number of mutations in conserved brain-related genes contributed to human evolution.

ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

Exosomes derived from BMSCs with miR-124-3p inhibitor protects against LPS-induced endometritis through regulation of DUSP6, p-p65 and p-ERK

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

Metabolic impact of trans 10, cis 12-conjugated linoleic acid on pai transgenic mice

This study investigates the long-term metabolic effects of t10c12-CLA in transgenic mice, finding increased brown fat and reduced white fat, along with elevated FGF21 and thermogenesis.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Geometric differences in the ribosome exit tunnel impact the escape of small nascent proteins

The paper investigates how geometric differences in ribosome exit tunnels affect the escape of small nascent proteins, finding that prokaryotes have higher escape probabilities than eukaryotes for short proteins.

ATG9 vesicles comprise the seed membrane of mammalian autophagosomes

This study identifies ATG9 vesicles as the seed membrane for mammalian autophagosomes, showing they integrate proteins like LC3-II and are diluted as autophagosomes expand.

Dynamics, signals and influencing factors of CD4 T cell activation revealed by single cell RNA-seq

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

Retinal metabolism: Evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

This paper investigates retinal energy metabolism, revealing that photoreceptors use distinct metabolic pathways, including the mini-Krebs, Cahill, and Cori cycles, to uncouple glycolysis from oxidative phosphorylation.

Integrating inflammatory biomarker analysis and artificial intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis

The paper identifies potential drug targets for intestinal fibrosis by combining image-based morphology analysis with AI and inflammatory biomarker measurements.