Alterations to the broad-spectrum formin inhibitor SMIFH2 improve potency
M. Orman, M. Landis, A. Oza, D. Nambiar, J. Gjeci, K. Song, V. Huang, A. Klestzick, C. Hachicho, S. Q. Liu, J. M. Kamm, F. Bartolini, J. J. Vadakkan, C. M. Rojas, C. L. Vizcarra
The paper tests SMIFH2 and its derivatives against human formins, finding that modifications enhance potency but do not allow distinction between conserved FH2 domains.
bioRxiv · Mar 10, 2022 · PreprintBiochemistry